Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance
Biol. Res
;
54: 41-41, 2021. ilus
Artículo
en Inglés
| LILACS
| ID: biblio-1505797
ABSTRACT
Cellular fate and gene expression patterns are modulated by different epigenetic factors including non-coding RNAs (ncRNAs) and chromatin organization. Both factors are dynamic throughout male germ cell differentiation on the seminiferous tubule, despite the transcriptional inactivation in the last stages of spermatogenesis. Sperm maturation during the caput-to-cauda transit on the epididymis involves changes in chromatin organization and the soma-to-germ line transference of ncRNAs that are essential to obtain a functional sperm for fertilization and embryo development. Here, the male environment (diseases, drugs, mental stress) is crucial to modulate these epigenetic factors throughout sperm maturation, affecting the corresponding offspring. Paternal transgenerational inheritance has been directly related to sperm epigenetic changes, most of them associated with variations in the ncRNA content and chromatin marks. Our aim is to give an overview about how epigenetics, focused on ncRNAs and chromatin, is pivotal to understand spermatogenesis and sperm maturation, and how the male environment impacts the sperm epigenome modulating the offspring gene expression pattern.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Cromatina
/
Epigénesis Genética
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad Austral de Chile/CL
/
Universidad Mayor/CL
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