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Pulmonary embolism in pediatrics: A 10-year experience from a tertiary center in Brazil
Lira, Liana Ariel de Siqueira; Celeste, Daniele Martins; Garanito, Marlene Pereira; Carneiro, Jorge David Aivazoglou.
  • Lira, Liana Ariel de Siqueira; Universidade de São Paulo (FMUSP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Celeste, Daniele Martins; Universidade de São Paulo (FMUSP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Garanito, Marlene Pereira; Universidade de São Paulo (FMUSP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Carneiro, Jorge David Aivazoglou; Universidade de São Paulo (FMUSP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
Hematol., Transfus. Cell Ther. (Impr.) ; 45(supl.2): S85-S90, July 2023. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1514208
ABSTRACT
ABSTRACT

Introduction:

Although still rare, pulmonary embolism (PE) in children has been increasing over the years. Data regarding this group of patients are still sparse, which contributes to the lack of standardized prophylaxis protocols and the misdiagnosis. This study aimed to determine the incidence of pediatric PE at a Brazilian tertiary hospital, describe clinical characteristics and identify possible risk factors. We also analyzed the diagnosis and management of PE.

Methods:

This was a retrospective review of tertiary Brazilian single-center data of all pediatric patients (0 - 18 years) with acute PE, diagnosed radiologically, from September 2009 to May 2019.

Results:

The incidence of PE was 3.3 cases per 10,000 hospitalized children. All the twenty-three cases had some risk factor identified and sixteen of them (69.5%) had more than one risk factor. The most important were central venous catheter (39.1%), malignancy (34.8%) and recent surgery (34.8%). Among the children with identifiable symptoms (69.5%), the most common was dyspnea (56.2%). Only one patient did not receive antithrombotic therapy because of the high bleeding risk and most patients (70.6%) were treated for 3 to 6 months. Among the nineteen patients alive at the end of the six-month follow-up, ten (52.6%) repeated the PE image control. Seven of them (70.0%) had complete or partial resolution of the thrombosis and none had worsening images.

Conclusion:

Our lower incidence than that of the current literature may reflect underdiagnosis due to low suspicion of PE. At least one risk factor was identified in all patients, which emphasizes the importance of increasing awareness of high-risk children.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Embolia Pulmonar / Tromboembolia / Niño / Adolescente Límite: Adolescente / Niño / Child, preschool / Humanos / Lactante / Recién Nacido País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Hematol., Transfus. Cell Ther. (Impr.) Asunto de la revista: Hematologia / TransfusÆo de Sangue Año: 2023 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo (FMUSP)/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Embolia Pulmonar / Tromboembolia / Niño / Adolescente Límite: Adolescente / Niño / Child, preschool / Humanos / Lactante / Recién Nacido País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Hematol., Transfus. Cell Ther. (Impr.) Asunto de la revista: Hematologia / TransfusÆo de Sangue Año: 2023 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo (FMUSP)/BR