Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;56: e0278, 2023. tab, graf
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LILACS-Express
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| ID: biblio-1514853
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BR1.1
ABSTRACT
ABSTRACT Introduction:
Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life of affected individuals.Methods:
In this study, patients underwent clinical follow-ups, joint biopsies, and pre-biopsy and 24 months post-biopsy serum dosage of cytokines.Results:
All participants were female and had pain in 12 joints on average, with 41.17% exhibiting moderate disease activity. Histopathological analysis revealed collagen deposition. Indirect immunofluorescence detected the CHIKV glycoprotein E1 antigen, and an increase in cytokines.Conclusions:
Persistent inflammation and ineffective antiviral immune responses leading to antigen persistence may contribute to chronic CHIKV arthritis.
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Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2023
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Article