Pancreatitis crónica: análisis de factores de progresión de la enfermedad / Chronic pancreatitis: analysis of disease progression factors
Rev. méd. Chile
; 150(12): 1555-1564, dic. 2022. tab, graf
Article
en Es
| LILACS
| ID: biblio-1515396
Biblioteca responsable:
CL1.1
ABSTRACT
BACKGROUND:
Alcohol and tobacco are important risk factors for chronic pancreatitis (CP).AIM:
To analyze the effect of etiological factors such as tobacco and alcohol and pancreatic enzyme replacement therapy (PERT) in the progression of CP. MATERIAL ANDMETHODS:
Patients with a diagnosis of CP were recruited and grouped according to variables such as tobacco, alcohol and PERT. They were followed for 18 months. Subsequently, different variables and analytical parameters involved in the progression of the disease were analyzed.RESULTS:
A total of 50 patients diagnosed with CP were included. Of these, 28 patients underwent PERT, 39 were smokers and 33 were alcohol users. Compared with patients without PERT, those with PERT had a higher proportion of diabetes (64 and 32%, respectively), had a higher need for endoscopic treatment (25 and 0%, respectively) and a normal body mass index (71 and 27.3%, respectively. The smokers had higher calcium levels and increased lymphocytosis and leukocytosis. The alcohol consumption group had a higher mean age (p = 0.04)CONCLUSIONS:
PERT may improve the nutritional status but does not reduce the need for endoscopic or surgical treatment. Smoking and alcohol consumption favored the progression of CP. Also, smoking induced a pro-inflammatory state.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Pancreatitis Crónica
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2022
Tipo del documento:
Article