Expression of Serum Vascular Endothelial Growth Factor and Angiopoietin Receptor Tie-2 in Essential Hypertension
West Indian med. j
;
69(7): 464-470, 2021. tab, graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1515708
ABSTRACT
ABSTRACT Objective:
To investigate the serum levels of a vascular endothelial growth factor (VEGF), an angiogenic factor and a soluble angiopoietin receptor Tie-2 (sTie-2) in patients with essential hypertension.Methods:
In the present study 90 individuals (56 males and 34 females, mean age 48 ± 7 years) have been divided into 3 groups 30 patients with hypertension, 30 healthy individuals with a family history of hypertension and 30 healthy individuals with no family history of hypertension. All individuals have been evaluated in terms of blood pressure and biochemical parameters. The levels of VEGF and Tie-2 receptor have been evaluated by using the enzyme-linked immunosorbent assay method.Results:
The findings suggested that the serum VEGF, sTie-2 receptor, low-density lipoprotein and triglycerides levels in the hypertensive patients were significantly higher than those in the control group (p < 0.05). However, the level of high-density lipoprotein cholesterol in the patients was significantly lower than in those in the control group (p < 0.05). In correlation analysis, a positive correlation was found statistically significant between the values of VEGF and sTie-2 (r = 0.405, p = 0.026).Conclusion:
As a result of this study, our data indicate that serum levels of VEGF and Tie-2 receptor may be related to the primary hypertension. This study could inspire to further studies to explore the roles of VEGF and Tie-2 receptor in essential hypertension.
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Índice:
LILACS (Américas)
Idioma:
Inglés
Revista:
West Indian med. j
Asunto de la revista:
Medicina
Año:
2021
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Turquía
Institución/País de afiliación:
Sivas Cumhuriyet University/TR
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