Comparative Assessment of E-cadherin's Expression between the Metastatic and Non-metastatic Oral Squamous Cell Carcinoma: An Immunohistochemical Study
Pesqui. bras. odontopediatria clín. integr
;
23: e220077, 2023. tab, graf
Artículo
en Inglés
| LILACS, BBO
| ID: biblio-1529117
ABSTRACT
ABSTRACT Objective: To identify the clinicopathological correlation of E-cadherin expression in metastatic and non-metastatic oral squamous cell carcinoma (OSCC). Material and Methods: A total of 90 paraffin-embedded tissue sections of OSCC were retrieved from the registry. The total selected samples were 45 cases each from the primary lesions of metastatic and non-metastatic OSCC. One section was subjected to routine Hematoxylin and eosin stain and another to immunohistochemical analysis for E-cadherin expression. Results: A non-significant (p˃0.05) increased expression is seen in the non-metastatic group compared to the metastatic group, with predominantly membrane as the staining site in either group. However, the expression of E-cadherin did not reveal any statistically significant association with independent variables such as age, gender, and adverse habits of the patients (p>0.05). On the other hand, with respect to the histological differentiation of OSCC, a significant association (p<0.001) was observed with the well-differentiated type of metastatic OSCC. Conclusion: E-cadherin was useful to some extent in predicting regional metastasis. However, further studies using a panel of biomarkers with increased sample size may help us understand the process involved in metastasis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Biomarcadores
/
Cadherinas
/
Adhesión Celular
/
Carcinoma de Células Escamosas de Cabeza y Cuello
Tipo de estudio:
Estudios de evaluación
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
Pesqui. bras. odontopediatria clín. integr
Asunto de la revista:
Odontología
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
India
/
Arabia Saudita
Institución/País de afiliación:
Awadh Dental College & Hospital/IN
/
Jouf University/SA
/
Shri Dharmasthala Manjunatheswara University/IN
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