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Combined administration of gallic acid and glibenclamide mitigate systemic complication and histological changes in the cornea of diabetic rats induced with streptozotocin
Zhao, Jing; Hussain, Shaik Althaf; Maddu, Narendra.
  • Zhao, Jing; Sanmenxia Central Hospital. Department of Ophthalmology. Sanmenxia. CN
  • Hussain, Shaik Althaf; King Saud University. College of Science. Department of Zoology. Riyadh. SA
  • Maddu, Narendra; Sri Krishnadevaraya University. Department of Biochemistry. Anantapur. IN
Acta cir. bras ; 39: e390124, 2024. tab, graf, ilus
Artículo en Inglés | LILACS, VETINDEX | ID: biblio-1533360
ABSTRACT

Purpose:

To determine the effect of gallic acid or its combination with glibenclamide on some biochemical markers and histology of the cornea of streptozotocin (STZ) induced diabetic rats.

Methods:

Following induction of diabetes, 24 male albino rats were divided into four groups of six rats each. Groups 1 and 2 (control and diabetic) received rat pellets and distilled water; group 3 (gallic acid) received rat pellets and gallic acid (10 mg/kg, orally) dissolved in the distilled water; and group 4 (gallic acid + glibenclamide) received rat pellets, gallic acid (10 mg/kg, orally), and glibenclamide (5 mg/kg, orally) dissolved in the distilled water. The treatments were administered for three months after which the rats were sacrificed after an overnight fast. Blood and sera were collected for the determination of biochemical parameters, while their eyes were excised for histology.

Results:

STZ administration to the rats induced insulin resistance, hyperglycemia, microprotenuria, loss of weight, oxidative stress, inflammation, and alteration of their cornea histology, which was abolished following supplementation with gallic acid or its combination with glibenclamide.

Conclusions:

The study showed the potentials of gallic acid and glibenclamide in mitigating systemic complication and histological changes in the cornea of diabetic rats induced with STZ.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Gliburida / Estreptozocina / Córnea / Diabetes Mellitus / Ácido Gálico Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2024 Tipo del documento: Artículo País de afiliación: China / India / Arabia Saudita Institución/País de afiliación: King Saud University/SA / Sanmenxia Central Hospital/CN / Sri Krishnadevaraya University/IN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Gliburida / Estreptozocina / Córnea / Diabetes Mellitus / Ácido Gálico Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2024 Tipo del documento: Artículo País de afiliación: China / India / Arabia Saudita Institución/País de afiliación: King Saud University/SA / Sanmenxia Central Hospital/CN / Sri Krishnadevaraya University/IN