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Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway
Yang, Faji; Gao, Hengjun; Niu, Zheyu; Ni, Qingqiang; Zhu, Huaqiang; Wang, Jianlu; Lu, Jun.
  • Yang, Faji; Shandong Provincial Hospital affiliated to Shandong First Medical University. Department of Hepatobiliary Surgery. Jinan. CN
  • Gao, Hengjun; Shandong Provincial Hospital affiliated to Shandong First Medical University. Department of Hepatobiliary Surgery. Jinan. CN
  • Niu, Zheyu; Shandong Provincial Hospital affiliated to Shandong First Medical University. Department of Hepatobiliary Surgery. Jinan. CN
  • Ni, Qingqiang; Shandong Provincial Hospital affiliated to Shandong First Medical University. Department of Hepatobiliary Surgery. Jinan. CN
  • Zhu, Huaqiang; Shandong Provincial Hospital affiliated to Shandong First Medical University. Department of Hepatobiliary Surgery. Jinan. CN
  • Wang, Jianlu; Shandong Provincial Hospital affiliated to Shandong First Medical University. Department of Hepatobiliary Surgery. Jinan. CN
  • Lu, Jun; Shandong Provincial Hospital affiliated to Shandong First Medical University. Department of Hepatobiliary Surgery. Jinan. CN
Braz. j. med. biol. res ; 57: e13229, fev.2024. graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1534065
ABSTRACT
Abstract The incidence of non-alcoholic fatty liver (NAFLD) remains high, and many NAFLD patients suffer from severe ischemia-reperfusion injury (IRI). Currently, no practical approach can be used to treat IRI. Puerarin plays a vital role in treating multiple diseases, such as NAFLD, stroke, diabetes, and high blood pressure. However, its role in the IRI of the fatty liver is still unclear. We aimed to explore whether puerarin could protect the fatty liver from IRI. C57BL/6J mice were fed with a high‐fat diet (HFD) followed by ischemia reperfusion injury. We showed that hepatic IRI was more severe in the fatty liver compared with the normal liver, and puerarin could significantly protect the fatty liver against IRI and alleviate oxidative stress. The PI3K-AKT signaling pathway was activated during IRI, while liver steatosis decreased the level of activation. Puerarin significantly protected the fatty liver from IRI by reactivating the PI3K-AKT signaling pathway. However, LY294002, a PI3K-AKT inhibitor, attenuated the protective effect of puerarin. In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway.


Texto completo: Disponible Índice: LILACS (Américas) Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2024 Tipo del documento: Artículo / Documento de proyecto País de afiliación: China Institución/País de afiliación: Shandong Provincial Hospital affiliated to Shandong First Medical University/CN

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Texto completo: Disponible Índice: LILACS (Américas) Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2024 Tipo del documento: Artículo / Documento de proyecto País de afiliación: China Institución/País de afiliación: Shandong Provincial Hospital affiliated to Shandong First Medical University/CN