An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus
J. venom. anim. toxins incl. trop. dis
;
30: e20230063, 2024. tab, graf
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1550522
ABSTRACT
Background:
In Colombia, several species of Buthidae scorpions belonging to the genera Centruroides and Tityus coexist, and their stings are considered life-threatening to humans because of their venom neurotoxins. Despite previous studies focusing on neurotoxins from these scorpion genera, little is known about the enzymes present in their venoms and their relationship with whole venom toxicity.Methods:
Here, using proteomic and biochemical protocols the enzymatic activities of the venoms of three Colombian scorpion species, C. margaritatus, T. pachyurus, and T. n. sp. aff. metuendus, were compared to establish the presence and absence of enzymes such as phospholipases, hyaluronidases, and proteases that could be related to venom toxicity.Results:
C. margaritatus was positive for hyaluronidases, T. n. sp. aff. metuendus for proteases, and T. pachyurus exhibited activity for all three mentioned enzymes.Conclusion:
This information provides valuable insights into the specific enzyme diversity of each species' venom and their potential role in venom toxicity, which could contribute to the development of better treatments and prevention strategies for scorpion envenomation.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Venenos de Escorpión
País/Región como asunto:
America del Sur
/
Colombia
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Asunto de la revista:
Toxicología
Año:
2024
Tipo del documento:
Artículo
País de afiliación:
Colombia
/
México
Institución/País de afiliación:
Universidad Nacional Autónoma de México/MX
/
Universidad Tecnológica de Pereira/CO
/
Universidad del Cauca/CO
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