Establishment and application of a new 4/6 infarct nephrectomy rat model for moderate chronic kidney disease
Acta cir. bras
;
39: e391324, 2024. tab, graf, ilus
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1556671
ABSTRACT
Purpose:
To develop a new 4/6 infarct nephrectomy (INx) model rat mimicking moderate chronic kidney disease (CKD) and to evaluate its application.Methods:
We modified the conventional 5/6 INx rat model to create the 4/6 INx model by ligating the renal artery branch to induce infarction of one-third of the left kidney after right kidney removal and compared biochemically and histologically both models. To demonstrate the application of the 4/6 INx model, the effects of a supplementary compound containing calcium carbonate, chitosan, palm shell activated charcoal etc., that is effective for both CKD and its complications, were compared between both models.Results:
Impairment of renal function in the 4/6 INx group was significantly more moderate than in the 5/6 INx group (P < 0.05). The 4/6 INx group showed less histological damage in kidney than in the 5/6 INx group. The supplementary compound did not improve CKD in the 5/6 INx group, but ameliorated elevation of blood urea nitrogen in the 4/6 INx group.Conclusions:
We developed the 4/6 INx model, which is more moderate than the conventional 5/6 INx model. This model could potentially demonstrate the effectiveness of drugs and supplements intended to prevent CKD and its progression.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Insuficiencia Renal Crónica
/
Animales de Laboratorio
/
Microcirugia
/
Nefrectomía
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2024
Tipo del documento:
Artículo
País de afiliación:
Japón
Institución/País de afiliación:
Keio University/JP
/
Nippon Veterinary and Life Science University/JP
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