E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion
Acta cir. bras
;
39: e391724, 2024. tab, ilus
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1556672
ABSTRACT
Purpose:
To investigate inflammation and cell adhesion molecules in the vagina after ovarian ischemia-reperfusion (IR) injury.Methods:
20 Wistar albino female rats were divided into two groups control, and IR groups. In IR group, blood flow was restricted for 2 hours for ovarian ischemia. Then, tissues were re-blood 2 hours for reperfusion. Vagina tissues were excised and processed for histopathological analysis. Histopathological and biochemical follow-ups were performed.Results:
Both malondialdehyde and myeloperoxidase values were increased in IR group compared to control group. Glutathione content was decreased in IR group compared to control group. Epithelial degeneration, inflammation, dilatation, and nuclear factor-κB (NF-κB) expression were increased in IR group compared to control group. E-cadherin expression was significantly decreased in IR group. In the IR group, E-cadherin showed a positive reaction in adenomas, gland-like cryptic structures, cellular junctions with clustered inflammatory cells. In the IR group, NF-κB expression was increased in basement membrane, inflammatory cells, in blood vessels.Conclusions:
Ovarian ischemia caused degeneration of epithelial cells in the vaginal region and disruptions in the cell junction complex, which leads to activation of E-cadherin and NF-κB signaling pathway and alterations in reproductive and embryonal development in the vaginal region.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Ovario
/
Reperfusión
/
Cadherinas
/
FN-kappa B
/
Ratas Wistar
/
Isquemia
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2024
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Dicle University/TR
/
Diyarlife Hospital/TR
/
Istanbul Bahcelievler Memorial Hospital/TR
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