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Experimental model of glucocorticoid-induced insulin resistance
Martínez, Beatriz Bertolaccini; Pereira, Ana Carolina Couto; Muzetti, Júlio Henrique; Telles, Fernando de Paiva; Mundim, Fiorita Gonzáles Lopes; Teixeira, Manoel Araújo.
  • Martínez, Beatriz Bertolaccini; Universidade do Vale do Sapucaí. School of Medicine. Postgraduate Program in Sciences Applied to Health. Pouso Alegre. BR
  • Pereira, Ana Carolina Couto; Universidade do Vale do Sapucaí. School of Medicine. Postgraduate Program in Sciences Applied to Health. Pouso Alegre. BR
  • Muzetti, Júlio Henrique; Universidade do Vale do Sapucaí. School of Medicine. Postgraduate Program in Sciences Applied to Health. Pouso Alegre. BR
  • Telles, Fernando de Paiva; Universidade do Vale do Sapucaí. School of Medicine. Postgraduate Program in Sciences Applied to Health. Pouso Alegre. BR
  • Mundim, Fiorita Gonzáles Lopes; Universidade do Vale do Sapucaí. School of Medicine. Postgraduate Program in Sciences Applied to Health. Pouso Alegre. BR
  • Teixeira, Manoel Araújo; Universidade do Vale do Sapucaí. School of Medicine. Postgraduate Program in Sciences Applied to Health. Pouso Alegre. BR
Acta cir. bras ; 31(10): 645-649, Oct. 2016. tab, graf
Artículo en Inglés | LILACS | ID: biblio-827650
ABSTRACT
ABSTRACT PURPOSE: To evaluate metabolic effects in experimental model of glucocorticoid-induced insulin resistance. METHODS: Twenty Wistar male rats were randomly divided into two groups, which were treated with intraperitoneally injected dexamethasone 1mg/Kg/day for ten days consecutively (Group D; n=10) and placebo (Group C; n=10). The variables analyzed were: from the first to the 10th day - body weight (before and after treatment); food and water daily consumption; on the 10th day - glycemia, insulinemia, HOMA-beta and HOMA-IR. The blood samples for laboratory analysis were obtained by intracardiac puncture. Also on the 10th day liver fragments were taken for analyzing glycogen and fattty. RESULTS: Group D animals compared to group C had: weight reduction (g), (D=226.5±24.7 vs C=295.0±25.4; p=0.001); increased glycemia (mmol/l) (D=19.5±2.1 vs C=14.2±3.1; p=0.0001); diminished insulinemia (mU/l) (D=0.2±0.1 vs C=2.0±0.4; p=0.0001); reduced HOMA-β (D=0.2±0.1 vs C=4.2±1.7; p=0.0002); diminished HOMA-IR (D=0.2±0.1 vs C=1.3±0.4; p=0.0002). Histological examination of the liver showed that 100% of group D and none of group C had moderate fatty. (p=0.2). CONCLUSION: Animals treated with glucocorticoid, in this experimental model, expressed hyperglycemia, hypoinsulinism and decreased peripheral insulin sensitivity.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Resistencia a la Insulina / Dexametasona / Glucocorticoides Tipo de estudio: Estudios de evaluación / Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2016 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade do Vale do Sapucaí/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Resistencia a la Insulina / Dexametasona / Glucocorticoides Tipo de estudio: Estudios de evaluación / Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2016 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade do Vale do Sapucaí/BR