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Hepatotoxicity and nephrotoxicity of 3-bromopyruvate in mice
Pan, Qiong; Sun, Yiming; Jin, Qili; Li, Qixiang; Wang, Qing; Liu, Hao; Zhao, Surong.
  • Pan, Qiong; Department of Pharmacy. CN
  • Sun, Yiming; Department of Pharmacy. CN
  • Jin, Qili; Department of Pharmacy. CN
  • Li, Qixiang; Department of Pharmacy. CN
  • Wang, Qing; Department of Pharmacy. CN
  • Liu, Hao; Department of Pharmacy. CN
  • Zhao, Surong; Department of Pharmacy. CN
Acta cir. bras ; 31(11): 724-729, Nov. 2016. graf
Artículo en Inglés | LILACS | ID: biblio-827660
ABSTRACT
ABSTRACT

PURPOSE:

To investigate the hepatotoxicity and nephrotoxicity of 3-Bromopyruvate (3BP) in mice.

METHODS:

Fifteen nude mice were grafted subcutaneously in the left flank with MDA-MB-231 cells, then all mice were divided into control group (PBS), 3BP group (8 mg/kg), positive group (DNR 0.8 mg/kg) when tumor volume reached approximately 100 mm3. 28 days later, tumors, livers and kidneys were stored in 4 % formalin solution and stained with hematoxylin and eosin staining. The Kunming mice experiment included control group (PBS), 3BP group (4mg/kg; 8mg/kg; 16mg/kg), positive group (DNR 0.8 mg/kg). 24 hours later, the blood were used for the determination of hepatic damage serum biomarkers. Livers were stored in 4 % formalin solution for the later detection.

RESULTS:

3BP at the dose of 8mg/kg had a good effect on inhibiting tumor growth in nude mice and did not damage liver and kidney tissues. Kunming mice experiment showed 3BP at the dose of 16mg/kg did damage to liver tissues.

CONCLUSION:

3-Bromopyruvate at the dose of suppressing tumor growth did not exhibit hepatotoxicity and nephrotoxicity in nude mice, and the effect on liver was confirmed in Kunming mice.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Piruvatos / Inhibidores Enzimáticos / Enfermedad Hepática Inducida por Sustancias y Drogas / Lesión Renal Aguda / Riñón / Hígado Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2016 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: Department of Pharmacy/CN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Piruvatos / Inhibidores Enzimáticos / Enfermedad Hepática Inducida por Sustancias y Drogas / Lesión Renal Aguda / Riñón / Hígado Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2016 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: Department of Pharmacy/CN