Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: an exploratory study / Cleft lip/palate and flour fortification with folic acid in Chile
Rev. méd. Chile
;
144(8): 1012-1019, ago. 2016. graf, tab
Artículo
en Español
| LILACS
| ID: biblio-830606
ABSTRACT
Background:
The effect of food fortification with folic acid on the incidence of lip-palate fissures (FLP) is under discussion.Aim:
To calculate the rate of hospital discharges due to cleft lip and palate (CLP) and explore whether they decreased after the start of folic acid fortification in Chile. Material andMethods:
The hospital discharge databases published by the Chilean Ministry of Health were analyzed. The trends of discharge rates due to CLP of children of less than one year of life (ICD-10 Q350-379 code) and live births (lb) were calculated from 1986 to 2012. Variables such as incidence of rubella, poverty rate, obesity in pregnant women, and percentage of women who smoked or drank alcohol in the last month were included. The relative risk (RR) of CLP pre-fortification (1986-1999) and post-fortification (2000-2010) was calculated. Mixed and Prais-Winsten models were used to adjust other variables.Results:
The hospital discharge rate due to CLP decreased from 1.88 x 1,000 lb during 1986-1996 to 1.68 x 1,000 lb (RR = 1.09 (95% CI 1.05-1.14, p < 0.001). Prais-Winsten and Mixed models, determined that folic acid fortification is the variable explaining this decrease. During 2004-2011, hospital discharge rates for cleft lip decreased but there was an increase in the figures for cleft lip and palate.Conclusions:
The 9% decrease in hospital discharge rates for CLP is concomitant with wheat folic acid fortification.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Alta del Paciente
/
Alimentos Fortificados
/
Labio Leporino
/
Fisura del Paladar
/
Ácido Fólico
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio pronóstico
Límite:
Humanos
/
Lactante
/
Recién Nacido
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital Roberto del Río/CL
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