Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar / Vitamin D and parathyroid hormone levels and bone mineral density in patients undergoing hematopoietic cell transplantation
Rev. méd. Chile
;
144(9): 1119-1124, set. 2016. graf, tab
Artículo
en Español
| LILACS
| ID: biblio-830620
ABSTRACT
Background:
Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis.Aim:
To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients andMethods:
Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT.Results:
Ninety patients were included, 53 were evaluated prior to HCT and 37 after HCT. They represent 73% of all patients undergoing HCT in the period. Median 25OHD was 12 ng/ml (range 4-41.4). Ninety seven percent of patients had levels considered insufficient and 85% compatible with deficiency. Median PTH was 60.5 pg/ml (range 21-186). Forty five percent of patients had secondary hyperparathyroidism. DXA was performed in 65 patients (prior to HCT in 54 and after HCT in 11). Of these, 11% had had a low bone mineral density.Conclusions:
Patients undergoing HCT have a high risk of vitamin D deficiency, secondary hyperparathyroidism and low bone mineral density.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hormona Paratiroidea
/
Vitamina D
/
Deficiencia de Vitamina D
/
Trasplante de Células Madre Hematopoyéticas
/
Hiperparatiroidismo Secundario
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Pontificia Universidad Católica de Chile/CL
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