In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
Clin. biomed. res
; 37(1): 33-37, 2017. tab, graf
Article
en En
| LILACS
| ID: biblio-833278
Biblioteca responsable:
BR18.1
Ubicación: BR18.1
ABSTRACT
Introduction:
Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder.Methods:
In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in X-ALD patients was evaluated.Results:
A significant reduction of GSH and sulfhydryl content was observed in X-ALD patients compared to the control group. Furthermore, 5 mM of NAC, in vitro, led to an increase in GSH content and sulfhydryl groups in these patients.Conclusion:
These data probably indicate that an adjuvant therapy with the antioxidant NAC could improve the oxidative imbalance in X-ALD patients(AU)Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Acetilcisteína
/
Compuestos de Sulfhidrilo
/
Adrenoleucodistrofia
/
Glutatión
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin. biomed. res
Asunto de la revista:
MEDICINA
Año:
2017
Tipo del documento:
Article