Blood transfusion-related immunomodulation
Clin. biomed. res
;
34(4): 333-341, 2014. ilus, tab
Artículo
en Inglés
| LILACS
| ID: biblio-834486
ABSTRACT
The phenomenon of transfusion-related immunomodulation (TRIM) has been studied since the observation of a higher kidney allograft survival in patients who had received a higher number of transfusions. Conversely, it has been suggested as one of the possible causes related to the development of infections in patients with multiple blood transfusions and/or after a major surgery, and has been also associated with a decreased function of natural killer cells (NK) and antigen-presenting cells (APCs), reduced cell-mediated immunity, and increased regulatory T cells (Tregs). This review aimed to conceptualize TRIM and discuss some aspects related to its mechanisms and the prevention of immunomodulatory events.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Antígenos de Grupos Sanguíneos
/
Conservación de la Sangre
/
Transfusión Sanguínea
/
Terapia de Inmunosupresión
/
Tolerancia al Trasplante
/
Procedimientos de Reducción del Leucocitos
/
Inmunomodulación
/
Antígenos HLA
Idioma:
Inglés
Revista:
Clin. biomed. res
Asunto de la revista:
Medicina
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hospital de Clínicas de Porto Alegre/BR
/
Universidade Federal do Rio Grande do Sul/BR
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