Stem cells from adipose tissue improve the time of wound healing in rats
Acta cir. bras
;
31(12): 821-825, Dec. 2016. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-837663
ABSTRACT
ABSTRACT PURPOSE:
To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats.METHODS:
Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed.RESULTS:
All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions.CONCLUSION:
Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Células Madre
/
Cicatrización de Heridas
/
Heridas y Lesiones
/
Tejido Adiposo
/
Trasplante de Células Madre
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Pará/BR
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