Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
Acta cir. bras
;
32(3): 194-202, Mar. 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-837694
ABSTRACT
Abstract Purpose:
To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats.Methods:
The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH.Results:
No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed.Conclusions:
Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Estilbenos
/
Carotenoides
/
Hepatectomía
/
Hígado
/
Antioxidantes
Tipo de estudio:
Estudios de evaluación
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Pontifícia Universidade Católica de Campinas/BR
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