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Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer
Zhang, Y; Chen, Q.
  • Zhang, Y; Nanchang University. Department of Obstetrics and Gynecology. Nanchang. CN
  • Chen, Q; Nanchang University. Department of Obstetrics and Gynecology. Nanchang. CN
Braz. j. med. biol. res ; 50(6): e6104, 2017. tab, graf
Artículo en Inglés | LILACS | ID: biblio-839305
ABSTRACT
Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias Ováricas / Biomarcadores de Tumor / Metaloproteinasas de la Matriz Límite: Femenino / Humanos Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2017 Tipo del documento: Artículo / Documento de proyecto País de afiliación: China Institución/País de afiliación: Nanchang University/CN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias Ováricas / Biomarcadores de Tumor / Metaloproteinasas de la Matriz Límite: Femenino / Humanos Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2017 Tipo del documento: Artículo / Documento de proyecto País de afiliación: China Institución/País de afiliación: Nanchang University/CN