Synthesis and evaluation of platinum complexes with potential antitumor activity
Braz. J. Pharm. Sci. (Online)
;
53(1): e15235, 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-839451
ABSTRACT
Abstract A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice with Ehrlich solid tumors and it was able to reduce the rate of tumor growth significantly during the first seven days. However, at the end of the experiments, there was no significant difference between the group of animals treated with 3 and the control group. The low solubility of the compound in the assay conditions can explain, at least in part, these results.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Platino (Metal)
/
Ensayos de Selección de Medicamentos Antitumorales
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de Minas Gerais/BR
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