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Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review
Cruz, Júlia Niehues da; Magro, Débora Delwing Dal; Lima, Daniela Delwing de; Cruz, José Geraldo Pereira da.
Afiliación
  • Cruz, Júlia Niehues da; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Magro, Débora Delwing Dal; Universidade Regional de Blumenau. Blumenau. BR
  • Lima, Daniela Delwing de; Universidade da Região de Joinville. Joinvile. BR
  • Cruz, José Geraldo Pereira da; Universidade da Região de Joinville. Joinvile. BR
Braz. J. Pharm. Sci. (Online) ; 53(1): e16102, 2017. tab, graf
Article en En | LILACS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-839466
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs and, in turn, decrease NMDA-mediated anxiety. This hypothesis will contribute to understanding the critical roles of simvastatin in treating anxiety via the NMDA receptor.
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Texto completo: 1 Índice: LILACS Asunto principal: Ansiedad / Colesterol / Simvastatina Tipo de estudio: Systematic_reviews Límite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2017 Tipo del documento: Article
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Texto completo: 1 Índice: LILACS Asunto principal: Ansiedad / Colesterol / Simvastatina Tipo de estudio: Systematic_reviews Límite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2017 Tipo del documento: Article