Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults
Rev. Inst. Med. Trop. Säo Paulo
;
59: e2, 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-842764
ABSTRACT
ABSTRACT Introduction:
The World Health Organization (WHO) recommends one single dose of the Yellow Fever (YF) vaccine based on studies of antibody persistency in healthy adults. We assessed the prevalence and titers of YF virus neutralizing antibodies in previously vaccinated persons aged ≥ 60 years, in comparison to younger adults. We also evaluated the correlation between antibody titers and the time since vaccination among participants who received one vaccine dose, and the seropositivity among participants vaccinated prior to or within the past 10 years.Methods:
previously vaccinated healthy persons aged ≥ 18 years were included. YF virus neutralizing antibody titers were determined by means of the 50% Plaque Reduction Neutralization Test.Results:
46 persons aged ≥ 60 years and 48 persons aged 18 to 59 years were enrolled. There was no significant difference in the prevalence of YF virus neutralizing antibodies between the two groups (p = 0.263). However, titers were significantly lower in the elderly (p = 0.022). There was no correlation between YF virus neutralizing antibody titers and the time since vaccination. There was no significant difference in seropositivity among participants vaccinated prior to or within the past 10 years.Conclusions:
the clinical relevance of the observed difference in YF virus neutralizing antibody titers between the two groups is not clear.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fiebre Amarilla
/
Virus de la Fiebre Amarilla
/
Vacuna contra la Fiebre Amarilla
/
Anticuerpos Neutralizantes
/
Anticuerpos Antivirales
Tipo de estudio:
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Asunto de la revista:
Medicina Tropical
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo, Faculdade de Medicina/BR
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