Clinical and nutritional factors associated with dialysis initiation and mortality in chronic kidney disease
Nutrire Rev. Soc. Bras. Aliment. Nutr
;
42: 1-5, Dec. 2017. tab
Artículo
en Inglés
| LILACS
| ID: biblio-881176
ABSTRACT
BACKGROUND: Chronic kidney disease is worldwide recognized as a public health problem due to high rates of morbidity and mortality. At the end stage of the disease, which the glomerular filtration rate is equal or less than15 ml/min/1.73 m2, dialysis initiation is usually indicated. In the absence of a consensus on the best time of beginning, the aim of this study was to identify clinical and nutritional factors associated with clinical outcomes with the start of dialysis and death. METHODS: In a prospective cohort of 82 patients, clinical (underlying renal disease, renal survival time, systolic and diastolic blood pressure, estimated glomerular filtration rate) and nutritional data (protein intake, anthropometry, bioelectrical impedance test, and strength handgrip) were collected. We used mean and standard deviation ormedian and association of the variables with the outcome entry into dialysis or death, and a Cox regression model was applied. Statistical significance wasp< 0.05.RESULTS: Fifty-eight patients were included in group 1G1 (without dialysis)and 24 patients in group 2G2(dialysis). The groups were different in blood urea nitrogen (p= <0.001), serum creatinine (p= 0.003), estimated glomerular filtration rate (p= 0.002), and serum phosphorus (p= 0.002). After multivariate analysis, only serumalbumin (HR 0.342,p= 0.004) and glomerular filtration rate (HR 0.001,p= 0.001) were associated with entry into dialysis and death. CONCLUSIONS: We concluded that lower levels of serum albumin and glomerular filtration rate values are associated with entry into dialysis or death.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Insuficiencia Renal Crónica
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Nutrire Rev. Soc. Bras. Aliment. Nutr
Asunto de la revista:
Ciencias Nutricionales
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
University Hospital/BR
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