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Colon epithelial cells luminal environment and physiopathological consequences: impact of nutrition and exercise
Blachier, François; Resende, Ayane de Sá; Leite, Geovana da Silva Fogaça; Costa, Aline Vasques da; Lancha Junior, Antonio Herbert.
  • Blachier, François; University of Sao Paulo. School of Physical Education and Sport. Laboratory of Applied Nutrition and Metabolism. São Paulo. BR
  • Resende, Ayane de Sá; University of Sao Paulo. School of Physical Education and Sport. Laboratory of Applied Nutrition and Metabolism. São Paulo. BR
  • Leite, Geovana da Silva Fogaça; University of Sao Paulo. School of Physical Education and Sport. Laboratory of Applied Nutrition and Metabolism. São Paulo. BR
  • Costa, Aline Vasques da; University of Sao Paulo. School of Physical Education and Sport. Laboratory of Applied Nutrition and Metabolism. São Paulo. BR
  • Lancha Junior, Antonio Herbert; University of Sao Paulo. School of Physical Education and Sport. Laboratory of Applied Nutrition and Metabolism. São Paulo. BR
Nutrire Rev. Soc. Bras. Aliment. Nutr ; 43: 1-9, Mar. 2018. ilus
Artículo en Inglés | LILACS | ID: biblio-881665
ABSTRACT
The colonic epithelial cells represent a border between the colon luminal content, containing notably bacteria and a complex mixture of compounds, and the"milieu interieur"as defined by the French physiologist Claude Bernard.The physical-chemical composition of the luminal content, including luminal pH and bacterial metabolite, that obviousl y is not constant, is modified for instance according to the diet. Data obtained recently indicate that physical exercise may also modify the colonic luminal content. Evidence has indicated that modification of the luminal content characteristics has, indeed, consequences for the colonic epithelial cells, notably in terms of energy metabolism and DNA integrity. Although such alterations impact presumably the homeostatic process of the colonic epithelium renewal and the epithelial barrier function, their contribution to pathological processes like mucosal inflammation, pre-neoplasia, and neoplasia remains partly elusive. Open questions remain regarding the individual and collective roles of luminal changes, particularly in a long-term perspective. These questions are related particularly to the capacity of the bacterial metabolites to cross the mucus layer before entering the colonocytes, to the concentrations of metabolites in proximity of the colonic crypt stem cells, and to the capacity of colonocytes to detoxicate deleterious compounds, to take up and utilize beneficial compounds.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Colon / Microbioma Gastrointestinal Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Nutrire Rev. Soc. Bras. Aliment. Nutr Asunto de la revista: Ciencias Nutricionales Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: University of Sao Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Colon / Microbioma Gastrointestinal Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Nutrire Rev. Soc. Bras. Aliment. Nutr Asunto de la revista: Ciencias Nutricionales Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: University of Sao Paulo/BR