Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury
Acta cir. bras
;
32(11): 949-955, Nov. 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-886182
ABSTRACT
Abstract Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats. Methods: 25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. Results: Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage. Conclusion: Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Solución Salina Hipertónica
/
Daño por Reperfusión
/
Precondicionamiento Isquémico
/
Sustancias Protectoras
/
Hígado
Tipo de estudio:
Factores de riesgo
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual do Para/BR
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