Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture
Acta cir. bras
;
32(11): 924-934, Nov. 2017. graf
Artículo
en Inglés
| LILACS
| ID: biblio-886184
ABSTRACT
Abstract Purpose:
To evaluate the influence of nandrolone decanoate on fracture healing and bone quality in normal rats.Methods:
Male rats were assigned to four groups (n=28/group) Control group consisting of animals without any intervention, Nandrolone decanoate (DN) group consisting of animals that received intramuscular injection of nandrolone decanoate, Fracture group consisting of animals with a fracture at the mid-diaphysis of the femur, and Fracture and nandrolone decanoate group consisting of animals with a femur fracture and treatment with nandrolone decanoate. Fractures were created at the mid-diaphysis of the right femur by a blunt trauma and internally fixed using an intramedullary steel wire. The DN was injected intramuscularly twice per week (10 mg/kg of body mass). The femurs were measured and evaluated by densitometry and mechanical resistance after animal euthanasia. The newly formed bone and collagen type I levels were quantified in the callus.Results:
The treated animals had longer femurs after 28 days. The quality of the intact bone was not significantly different between groups. The bone callus did show a larger mass in the treated rats.Conclusion:
The administration of nandrolone decanoate did not affect the quality of the intact bone, but might have enhanced the bone callus formation.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Callo Óseo
/
Curación de Fractura
/
Fracturas del Fémur
/
Anabolizantes
/
Nandrolona
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
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