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Effect of mild hypothermia on renal ischemia/reperfusion injury after cardiopulmonary resuscitation in a swine model
Yuan, Wei; Wu, Jun-Yuan; Zhao, Yong-Zhen; Li, Jie; Li, Jie-Bin; Li, Zhen-Hua; Li, Chun-Sheng.
Afiliación
  • Yuan, Wei; Capital Medical University. Beijing Chao-Yang Hospital. Department of Emergency. Beijing. CN
  • Wu, Jun-Yuan; Capital Medical University. Beijing Chao-Yang Hospital. Department of Emergency. Beijing. CN
  • Zhao, Yong-Zhen; Capital Medical University. Beijing Chao-Yang Hospital. Department of Emergency. Beijing. CN
  • Li, Jie; Capital Medical University. Beijing Chao-Yang Hospital. Department of Emergency. Beijing. CN
  • Li, Jie-Bin; Capital Medical University. Beijing Chao-Yang Hospital. Department of Emergency. Beijing. CN
  • Li, Zhen-Hua; Capital Medical University. Beijing Chao-Yang Hospital. Department of Emergency. Beijing. CN
  • Li, Chun-Sheng; Capital Medical University. Beijing Chao-Yang Hospital. Department of Emergency. Beijing. CN
Acta cir. bras ; 32(7): 523-532, July 2017. tab, graf
Article en En | LILACS | ID: biblio-886215
Biblioteca responsable: BR1.1
ABSTRACT
Abstract

Purpose:

To investigate the effect of intravascular cooling on renal function after resuscitation.

Methods:

Twenty four pigs were randomized into three groups (n=8 in each group) therapeutic hypothermia group (TH group), normothermia group (NH group) and sham operation group (SHAM group). After 6 minutes of untreated VF, CPR was performed. Upon ROSC, the TH group received the intravascular cooling. The NH and SHAM group did not undergo therapeutic hypothermia. Haemodynamic parameters were recorded. The bloods were analyzed for serum creatinine (sCr), CysC and NGAL. The kidney was surgically removed observe pathologic changes under a light microscope.

Results:

The sCr increased in both TH and NH groups after ROSC, compared to baseline. Between two groups, the sCr and creatinine clearance (Cc) showed lower level in the TH group. The urine volume per hour in the TH group were higher during cooling. After resuscitation, NGAL and CysC in the NH group were higher than in the TH group. Under the light microscope, compared with the TH group, the renal injury was prominent in the NH group.

Conclusion:

Mild hypothermia had a protection to renal ischemia reperfusion injury after resuscitation.
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Texto completo: 1 Índice: LILACS Asunto principal: Daño por Reperfusión / Reanimación Cardiopulmonar / Hipotermia Inducida / Riñón Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Año: 2017 Tipo del documento: Article

Texto completo: 1 Índice: LILACS Asunto principal: Daño por Reperfusión / Reanimación Cardiopulmonar / Hipotermia Inducida / Riñón Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Año: 2017 Tipo del documento: Article