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Experimental study of peripheral-blood pro-surfactant protein B for screening non-small cell lung cancer
He, Yong; Jiang, Zhenjie; Tong, Fengzhi; Li, Mingwu; Yin, Xingru; Hu, Shixin; Wang, Linlin.
Afiliación
  • He, Yong; People's Hospital of Dalian. Department of Thoracic Surgery. CN
  • Jiang, Zhenjie; People's Hospital of Dalian. Department of Thoracic Surgery. CN
  • Tong, Fengzhi; People's Hospital of Dalian. Department of Thoracic Surgery. CN
  • Li, Mingwu; People's Hospital of Dalian. Department of Thoracic Surgery. CN
  • Yin, Xingru; People's Hospital of Dalian. Department of Thoracic Surgery. CN
  • Hu, Shixin; People's Hospital of Dalian. Department of Thoracic Surgery. CN
  • Wang, Linlin; People's Hospital of Dalian. Department of Thoracic Surgery. CN
Acta cir. bras ; 32(7): 568-575, July 2017. tab
Article en En | LILACS | ID: biblio-886221
Biblioteca responsable: BR1.1
ABSTRACT
Abstract

Purpose:

To evaluate the possibility of using peripheral-blood presurfactant protein B (Pro-SFTPB) for screening non-small cell lung cancer (NSCLC).

Methods:

A total of 873 healthy volunteers and 165 lung cancer patients hospitalized in the Fifth People's Hospital of Dalian were tested Pro-SFTPB once every half year from January 2014 to September 2015. The healthy volunteers were also conducted spiral computed tomography (CT) examination once every year. The data were then com-pared and statistically analyzed.

Results:

The positive expression rate of Pro-SFTPB in NSCLC was significantly higher than that in healthy volunteers, and significantly higher in lung adenocarcinoma than in squamous cell carcinoma; additionally, the expression rate was increased with the in-crease of smoking index, and the intergroup differences showed statistical signifi-cance (p≤0.05). The positive rate of newly diagnosed lung cancer was 29.55%, higher than healthy volunteers (22.34%), but there was no significant difference (p>0.05).

Conclusion:

Pro-SFTPB is over expressed in non-small cell lung cancer, especially in lung adeno-carcinoma, but it can't be used as a clinical screening tool for lung cancer.
Asunto(s)
Palabras clave

Texto completo: 1 Índice: LILACS Asunto principal: Precursores de Proteínas / Carcinoma de Pulmón de Células no Pequeñas / Proteínas Asociadas a Surfactante Pulmonar / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Acta cir. bras Asunto de la revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Año: 2017 Tipo del documento: Article

Texto completo: 1 Índice: LILACS Asunto principal: Precursores de Proteínas / Carcinoma de Pulmón de Células no Pequeñas / Proteínas Asociadas a Surfactante Pulmonar / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Acta cir. bras Asunto de la revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Año: 2017 Tipo del documento: Article