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Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs
Oliveira, André Lacerda de Abreu; Scheffer, Jussara Peters; Markoski, Melissa; Koche, Andreia; Balbinot, Alexsandra; Antunes, Fernanda; Kalil, Renato.
  • Oliveira, André Lacerda de Abreu; Universidade Estadual do Norte Fluminense Darcy Ribeiro. Animal Experimentation Unit. Center for Agricultural Sciences and Technologies. Campos dos Goytacazes. BR
  • Scheffer, Jussara Peters; Universidade Estadual do Norte Fluminense Darcy Ribeiro. Animal Experimentation Unit. Center for Agricultural Sciences and Technologies. Campos dos Goytacazes. BR
  • Markoski, Melissa; Universidade Estadual do Norte Fluminense Darcy Ribeiro. Animal Experimentation Unit. Center for Agricultural Sciences and Technologies. Campos dos Goytacazes. BR
  • Koche, Andreia; Universidade Estadual do Norte Fluminense Darcy Ribeiro. Animal Experimentation Unit. Center for Agricultural Sciences and Technologies. Campos dos Goytacazes. BR
  • Balbinot, Alexsandra; Universidade Estadual do Norte Fluminense Darcy Ribeiro. Animal Experimentation Unit. Center for Agricultural Sciences and Technologies. Campos dos Goytacazes. BR
  • Antunes, Fernanda; Universidade Estadual do Norte Fluminense Darcy Ribeiro. Animal Experimentation Unit. Center for Agricultural Sciences and Technologies. Campos dos Goytacazes. BR
  • Kalil, Renato; Universidade Estadual do Norte Fluminense Darcy Ribeiro. Animal Experimentation Unit. Center for Agricultural Sciences and Technologies. Campos dos Goytacazes. BR
Acta cir. bras ; 33(4): 386-395, Apr. 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-886279
ABSTRACT
Abstract

Purpose:

To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction.

Methods:

Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the diagonal branch of the paraconal coronary. They were divided into 4 groups one control group and 3 treatment groups (cell therapy and gene cell therapy). Echocardiography reviews were performed on three occasions and histopathological analysis was performed after 4 weeks. Analysis of variance (ANOVA), Tukey and Wilcoxon tests, were performed.

Results:

Association of vascular endothelial growth factor (VEGF) with angiopoietin1 (Ang1) presented satisfactory results in the improvement of ventricular function following ischemic cardiomyopathy in mini pigs when compared to the results of the other treated groups.

Conclusion:

The therapy with VEGF and the combination of VEGF with Ang1, promoted recovered function of the myocardium, characterized by reduced akinetic area and induction of neovascularization.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Terapia Genética / Función Ventricular / Angiopoyetina 1 / Factor A de Crecimiento Endotelial Vascular / Tratamiento Basado en Trasplante de Células y Tejidos / Infarto del Miocardio Tipo de estudio: Estudios de evaluación / Estudio pronóstico / Factores de riesgo Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Estadual do Norte Fluminense Darcy Ribeiro/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Terapia Genética / Función Ventricular / Angiopoyetina 1 / Factor A de Crecimiento Endotelial Vascular / Tratamiento Basado en Trasplante de Células y Tejidos / Infarto del Miocardio Tipo de estudio: Estudios de evaluación / Estudio pronóstico / Factores de riesgo Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Estadual do Norte Fluminense Darcy Ribeiro/BR