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Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables
MONSALVE, BERNARDITA; CONCHA-MEYER, ANIBAL; PALOMO, IVÁN; FUENTES, EDUARDO.
  • MONSALVE, BERNARDITA; Universidad de Talca. Interdisciplinary Excellence Research Program on Healthy Aging. Faculty of Health Sciences. Talca. CL
  • CONCHA-MEYER, ANIBAL; Universidad de Talca. Interdisciplinary Excellence Research Program on Healthy Aging. Faculty of Health Sciences. Talca. CL
  • PALOMO, IVÁN; Universidad de Talca. Interdisciplinary Excellence Research Program on Healthy Aging. Faculty of Health Sciences. Talca. CL
  • FUENTES, EDUARDO; Universidad de Talca. Interdisciplinary Excellence Research Program on Healthy Aging. Faculty of Health Sciences. Talca. CL
An. acad. bras. ciênc ; 89(1,supl): 615-633, May. 2017. graf
Artículo en Inglés | LILACS | ID: biblio-886649
ABSTRACT
ABSTRACT The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including the presence of cardiovascular disease risk factors, the endothelium loses its protective role and becomes a proatherosclerotic structure. In this article we searched for strategies from PUBMED and Science Direct databases using the following key words endothelium, natural bioactive compounds, polyphenols and cardiovascular diseases. The search was restricted to english language papers. Studies have identified the contribution of diet to the risk of developing cardiovascular diseases. In this context, high intakes of fruit and vegetables are associated with the decrease of cardiovascular diseases. Thus the most important fruit/vegetables and bioactive compounds to prevent endothelial diseases are berries, apples, virgin olive oil, tomatoes, soybeans, and polyphenols, carotenoids and unsaturated fatty acids, respectively. The bioactive compounds from fruit and vegetables provide endothelial protection through the following mechanisms improved eNOS/NO bioavailability, attenuates oxidative stress, inhibited NF-κB pathway and decreased cell adhesion molecules expression. In this article natural bioactive compound mechanisms of endothelium protection are thoroughly reviewed.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Verduras / Endotelio Vascular / Sustancias Protectoras / Dieta Mediterránea / Frutas Tipo de estudio: Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: An. acad. bras. ciênc Asunto de la revista: Ciencia Año: 2017 Tipo del documento: Artículo País de afiliación: Chile Institución/País de afiliación: Universidad de Talca/CL

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Verduras / Endotelio Vascular / Sustancias Protectoras / Dieta Mediterránea / Frutas Tipo de estudio: Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: An. acad. bras. ciênc Asunto de la revista: Ciencia Año: 2017 Tipo del documento: Artículo País de afiliación: Chile Institución/País de afiliación: Universidad de Talca/CL