Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
An. acad. bras. ciênc
;
89(3): 1369-1379, July-Sept. 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-886755
ABSTRACT
ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Triterpenos
/
Lamiaceae
/
Triterpenos Pentacíclicos
/
Fabaceae
/
Antineoplásicos
Límite:
Humanos
Idioma:
Inglés
Revista:
An. acad. bras. ciênc
Asunto de la revista:
Ciencia
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal da Bahia/BR
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