How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?
An. bras. dermatol
;
92(6): 826-829, Nov.-Dec. 2017. tab
Artículo
en Inglés
| LILACS
| ID: biblio-887130
ABSTRACT
Abstract: Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Psoriasis
/
Molécula 1 de Adhesión Intercelular
/
Síndrome de Fuga Capilar
/
Factor A de Crecimiento Endotelial Vascular
Límite:
Humanos
Idioma:
Inglés
Revista:
An. bras. dermatol
Asunto de la revista:
Dermatologia
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade do Estado do Rio de Janeiro/BR
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