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Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis
Silvestre, Marilene Chaves; Sato, Maria Notomi; Reis, Vitor Manoel Silva dos.
  • Silvestre, Marilene Chaves; Universidade Federal de Goiás. Department of Tropical Medicine and Dematology. Goiânia. BR
  • Sato, Maria Notomi; Universidade Federal de Goiás. Department of Tropical Medicine and Dematology. Goiânia. BR
  • Reis, Vitor Manoel Silva dos; Universidade Federal de Goiás. Department of Tropical Medicine and Dematology. Goiânia. BR
An. bras. dermatol ; 93(2): 242-250, Mar.-Apr. 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-887186
ABSTRACT
Abstract Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TNF, IL-1β, and IL-18, contributing to the development of Allergic Contact Dermatitis. Dendritic cells recognize and process antigenic peptides into T cells. Neutrophils cause pro-inflammatory reactions, mast cells induce migration/maturation of skin DCs, the natural killer cells have natural cytotoxic capacity, the γδ T cells favor contact with hapten during the sensitization phase, and the innate lymphoid cells act in the early stages by secreting cytokines, as well as act in inflammation and tissue homeostasis. The antigen-specific inflammation is mediated by T cells, and each subtype of T cells (Th1/Tc1, Th2/Tc2, and Th17/Tc17) activates resident skin cells, thus contributing to inflammation. Skin's regulatory T cells have a strong ability to inhibit the proliferation of hapten-specific T cells, acting at the end of the Allergic Contact Dermatitis response and in the control of systemic immune responses. In this review, we report how cutaneous innate immunity is the first line of defense and focus its role in the activation of the adaptive immune response, with effector response induction and its regulation.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Piel / Linfocitos T / Dermatitis Alérgica por Contacto / Inmunidad Innata Límite: Humanos Idioma: Inglés Revista: An. bras. dermatol Asunto de la revista: Dermatologia Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal de Goiás/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Piel / Linfocitos T / Dermatitis Alérgica por Contacto / Inmunidad Innata Límite: Humanos Idioma: Inglés Revista: An. bras. dermatol Asunto de la revista: Dermatologia Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal de Goiás/BR