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Intravenous immunoglobulin therapy among pediatric patients: labeled and off-labeled indications
Toh, Chin Chiang; Islahudin, Farida; Ali, Adli; Shah, Noraida Mohamed.
  • Toh, Chin Chiang; Universiti Kebangsaan Malaysia. Faculty of Pharmacy. Kuala Lumpur. MY
  • Islahudin, Farida; Universiti Kebangsaan Malaysia. Faculty of Pharmacy. Kuala Lumpur. MY
  • Ali, Adli; Universiti Kebangsaan Malaysia. Faculty of Medicine. Pediatric Department. Kuala Lumpur. MY
  • Shah, Noraida Mohamed; Universiti Kebangsaan Malaysia. Faculty of Pharmacy. Kuala Lumpur. MY
Braz. J. Pharm. Sci. (Online) ; 54(1): e00008, 2018. tab
Artículo en Inglés | LILACS | ID: biblio-889445
ABSTRACT
ABSTRACT This study was designed to evaluate utilization patterns and clinical outcome of intravenous immunoglobulin (IVIG) therapy among pediatric patients in a tertiary hospital. Demographic data, IVIG prescribed, and clinical outcome were retrospectively reviewed from the pharmacy dispensing data and patient medical records between 2007 and 2014. One hundred and fifteen instances of IVIG administration to 108 pediatric patients were recorded. A total of 61 cases (53%) and 54 cases (47%) of the IVIG administered were for labeled and off-labeled indications, respectively. Age, weight, specialty, total IVIG usage, length of hospital stays, and mortality rate were found to be significantly associated with the indication being labeled or off-labeled (p<0.05). However, there was no significant difference in terms of adverse reactions between labeled and off-labeled indications (p>0.05). Guidelines should be developed and implemented for rational and evidence-based use of IVIG to avoid unnecessary wastage.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Terapéutica / Salud Infantil / Inmunoglobulinas Intravenosas Tipo de estudio: Guía de Práctica Clínica Límite: Niño / Child, preschool / Humanos / Lactante / Recién Nacido Idioma: Inglés Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2018 Tipo del documento: Artículo País de afiliación: Malasia Institución/País de afiliación: Universiti Kebangsaan Malaysia/MY

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Terapéutica / Salud Infantil / Inmunoglobulinas Intravenosas Tipo de estudio: Guía de Práctica Clínica Límite: Niño / Child, preschool / Humanos / Lactante / Recién Nacido Idioma: Inglés Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2018 Tipo del documento: Artículo País de afiliación: Malasia Institución/País de afiliación: Universiti Kebangsaan Malaysia/MY