Antivenom therapy: efficacy of premedication for the prevention of adverse reactions
J. venom. anim. toxins incl. trop. dis
;
24: 7, 2018. tab
Artículo
en Inglés
| LILACS
| ID: biblio-894169
ABSTRACT
Antivenoms or antitoxins have been effectively used for more than a century. During this time, these products have always proven to be highly effective in the treatment of infections and envenomations. However, antivenoms did not exhibit good safety results in their initial applications. After many improvements, antivenoms have substantially better safety profiles but still have some side effects. Due to the occurrence of adverse reactions, the practice of using premedication with the intent to decrease side effects has become accepted or mandatory in many countries. The drugs used for premedication belong to the histamine H1 antagonist, glucocorticoid and catecholamine groups. Currently, this practice is being questioned due to low or controversial efficacies in clinical assays. In this article, we discuss the causes of adverse reactions, the mechanisms of drugs that block the undesired effects and the results obtained in clinical trials. Although these three families of drugs could have positive effects on reducing adverse reactions, only adrenaline has demonstrated positive results in clinical assays.(AU)
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Índice:
LILACS (Américas)
Asunto principal:
Premedicación
/
Mordeduras de Serpientes
/
Hidrocortisona
/
Antivenenos
/
Epinefrina
/
Antagonistas de los Receptores Histamínicos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Asunto de la revista:
Toxicología
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Uruguay
Institución/País de afiliación:
University of the Republic/UY
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