Cytotoxic activity in cutaneous leishmaniasis
Mem. Inst. Oswaldo Cruz
;
112(11): 733-740, Nov. 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-894850
ABSTRACT
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Células Asesinas Naturales
/
Linfocitos T Citotóxicos
/
Leishmaniasis Cutánea
/
Linfocitos T CD8-positivos
/
Citotoxicidad Inmunológica
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2017
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal da Bahia/BR
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