Changes in serum cardiac myosin light chain 1 levels in children with fulminant myocarditis during continuous blood purification
Rev. Assoc. Med. Bras. (1992)
;
63(10): 904-909, Oct. 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-896298
ABSTRACT
Summary Objective: To investigate the changes in serum cardiac myosin light chain 1 (CMLC-1) levels in children with fulminant myocarditis (FM) during continuous blood purification (CBP), as well as to analyze its correlation with other laboratory indexes. Method: Twenty-four (24) children with FM who underwent CBP were enrolled. Before and during treatment (48 and 72 hours after treatment, or death), the optical density value of serum CMLC-1 was measured using enzyme-linked immunosorbent assay, and then the serum CMLC-1 concentration was calculated. The correlations between CMLC-1 OD value change and laboratory indexes including creatine kinase-MB (CK-MB), troponin, myohemoglobin and N-terminal pro-brain natriuretic peptide (NT-proBNP) were analyzed. Results: The serum CMLC-1 concentration significantly increased in the children with FM and decreased obviously during CBP therapy. In the same period, the change of CMLC-1 concentration were positively correlated with creatine kinase-MB (r=0.528), troponin (r=0.726), myohemoglobin (r=0.702), and NT-proBNP levels (r=0.589). Conclusion: The serum CMLC-1 concentration increases significantly in children with FM, but CBP therapy can effectively control this increase.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hemofiltración
/
Cadenas Ligeras de Miosina
/
Miocarditis
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Rev. Assoc. Med. Bras. (1992)
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Jilin University/CN
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