Micrornas and current concepts on the pathogenesis of abdominal aortic aneurysm
Rev. bras. cir. cardiovasc
;
32(3): 215-224, May-June 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-897914
ABSTRACT
Abstract Objective:
Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Aorta Abdominal
/
Aneurisma de la Aorta Abdominal
/
MicroARNs
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. bras. cir. cardiovasc
Asunto de la revista:
Cardiología
/
Cirugía General
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
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