Molecular typing of human platelet antigens in immune thrombocytopenia patients in northern Brazil
Rev. bras. hematol. hemoter
;
39(2): 122-126, Apr.-June 2017. tab
Artículo
en Inglés
| LILACS
| ID: biblio-898916
ABSTRACT
ABSTRACT Background:
Immune thrombocytopenia is an immune disease characterized by thrombocytopenia and bleeding due to platelet antibodies against platelet membrane glycoproteins. Human platelet antigens are derived from polymorphisms of these glycoproteins. The aim of this study was to investigate human platelet antigen frequencies in immune thrombocytopenia patients from the state of Amazonas, Brazil and investigate the potential association between specific antigens and risk for immune thrombocytopenia.Method:
Human platelet antigen typing was performed by BeadChip technology to determine allelic variants of 11 systems (HPA-1 to HPA-9, HPA-11 and HPA-15). Thirty-six patients (8 male and 28 female) with a median age of 34 years (range 9-69 years) were evaluated and compared with data from Amazonas blood donors.Results:
Platelet counts varied from 3 to 98 × 109/L. The allele frequencies were 0.944 for HPA-1a, 0.056 for HPA-1b, 0.847 for HPA-2a, 0.153 for HPA-2b, 0.555 for HPA-3a, 0.444 for HPA-3b, 0.805 for HPA-5a, 0.222 for HPA-5b, 0.9975 for HPA-9a, 0.025 for HPA-9b, 0.486 for HPA-15a and 0.513 for HPA-15b. Among immune thrombocytopenia individuals, no b allele of the HPA-4, -6, -7, -8 and -11 were found.Conclusions:
The results suggest HPA-1a, HPA-3b and HPA-5b are immune thrombocytopenia-specific autoepitopes.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Plaquetas
/
Púrpura Trombocitopénica Idiopática
/
Antígenos de Plaqueta Humana
/
Tipificación Molecular
/
Técnicas de Genotipaje
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Rev. bras. hematol. hemoter
Asunto de la revista:
Hematología
Año:
2017
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade do Estado do Amazonas/BR
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