Survival outcome among patients with Ewing's sarcoma of bones and joints: a population-based cohort study
São Paulo med. j
;
136(2): 116-122, Mar.-Apr. 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-904155
ABSTRACT
ABSTRACT BACKGROUND:
The aim here was to elucidate the current survival condition of patients diagnosed with Ewing's sarcoma of the bones and joints and determine independent risk factors associated with the prognosis. DESIGN ANDSETTING:
Retrospective cohort study based on the Surveillance, Epidemiology and End Results (SEER) database in the United States.METHODS:
We identified 397 patients who were diagnosed with Ewing's sarcoma of the bones and joints between January 2004 and December 2013. The multivariate Cox proportional hazards model was used to determine factors associated with the risk of death by adjusting for various factors.RESULTS:
The one, two and five-year disease-specific survival rates were 89.08%, 78.08% and 62.47%, respectively. The factors related to death were age (≥ 18 years versus < 18 years; hazard ratio, HR = 1.77; 95% confidence interval, CI 1.38-2.31); tumor site (extremity versus spine and pelvis; HR = 2.03; 95% CI 1.31-2.62); tumor size (> 10 cm versus ≤ 10 cm; HR = 1.78; 95% CI 1.34-2.56); and type of treatment (surgery alone versus radiotherapy with surgery; HR = 0.51; 95% CI 0.38-0.89; or radiotherapy alone versus radiotherapy with surgery; HR = 1.61; 95% CI 1.10-2.39; or no treatment versus radiotherapy with surgery; HR = 1.86; 95% CI 1.23, 2.58).CONCLUSIONS:
Patients with Ewing's sarcoma showed poor survival in situations of age ≥ 18 years, tumor size > 10 cm, receiving radiotherapy alone and receiving no treatment. Patients undergoing surgery alone had better survival.
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Índice:
LILACS (Américas)
Asunto principal:
Sarcoma de Ewing
/
Neoplasias Óseas
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Wuhan University/CN
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