Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation
Autops. Case Rep
;
8(3): e2018035, July-Sept. 2018. ilus
Artículo
en Inglés
| LILACS
| ID: biblio-911896
ABSTRACT
Papilloma associated with recurrent respiratory papillomatosis (RRP), caused by human papilloma virus (HPV) infection types 6 and 11, is the most common benign neoplasm of the larynx. The clinical features of RRP vary widely from mild to aggressive forms. RRP in children is known as juvenile-onset recurrent respiratory papillomatosis (JORRP). Its outcome may be poor or even fatal due to the high rate of recurrence and eventual spread to the entire respiratory tract. Pulmonary invasion is reported to occur in 3.3% of patients with RRP, and malignant transformation in 0.5% of patients. We report the case of a 39-year-old female patient with a diagnosis of JORRP from the age of 3 years, with extensive bilateral pulmonary involvement and malignant transformation. Analysis of the papilloma and carcinomatous tissues revealed the presence of HPV type 11, which is associated with rapid and aggressive progression. We discussed the case on the basis of a literature review on pulmonary invasion, malignant transformation, and HPV 11 aggressiveness.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Carcinoma de Células Escamosas
/
Infecciones por Papillomavirus
/
Neoplasias Pulmonares
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Autops. Case Rep
Asunto de la revista:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Instituto do Cancer do Estado de Sao Paulo/BR
/
Irmandade da Santa Casa de Misericordia de Sao Paulo/BR
/
Santa Casa de Sao Paulo School of Medical Sciences/BR
/
Universidade de Sao Paulo/BR
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