Antifungal Activity of Eugenol and its Association with Nystatin on Candida albicans
Pesqui. bras. odontopediatria clín. integr
;
17(1): e3235, 13/01/2017. tab
Artículo
en Inglés
| LILACS, BBO
| ID: biblio-914261
ABSTRACT
Objective:
To evaluate the anti-Candida effect of eugenol and its antimicrobial interaction with nystatin. Material andMethods:
The antimicrobial potential was assessed by microdilution technique (M27A3 reference method), by determining the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) against C. albicans (ATCC 90028). The possible action of eugenol on the fungal cell wall was evaluated with the assistance of the osmotic protector sorbitol (0.8 M). The antimicrobial interaction with nystatin was assessed through the checkerboard method. All tests were performed in triplicate.Results:
All groups showed reductions in PI and GBI values and improvements in oral health knowledge, but IG1 and IG2 showed statistically significant differences in these variables compared to CG.Conclusion:
The eugenol has antifungal activity against C. albicans and its mechanism of action is probably not related to damage to the fungal cell wall. Association between eugenol and nystatin was not found to be an advantageous possibility for growth inhibition of C. albican.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Candida albicans
/
Eugenol
/
Sinergismo Farmacológico
/
Antibacterianos
Tipo de estudio:
Estudios de evaluación
/
Factores de riesgo
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Pesqui. bras. odontopediatria clín. integr
Asunto de la revista:
Odontología
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Paraíba/BR
/
State University of Paraíba/BR
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