Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model
Acta cir. bras
;
33(5): 420-430, May 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-949349
ABSTRACT
Abstract Purpose:
To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant.Methods:
Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV red propolis 100 mg/kg, GII and GVI celecoxib 20 mg/kg, GIII and GVII 1% gum arabic 5 mL/kg, GIV and GVIII distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E).Results:
In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001).Conclusion:
Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Própolis
/
Prótesis e Implantes
/
Tapones Quirúrgicos de Gaza
/
Inflamación
/
Neovascularización Patológica
Tipo de estudio:
Investigación cualitativa
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
UFC/BR
/
Universidade Federal do Ceará/BR
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