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Association between undercarboxylated osteocalcin, bone mineral density, and metabolic parameters in postmenopausal women
Zanatta, Leila C B; Boguszewski, Cesar L; Borba, Victoria Z C; Moreira, Carolina A.
  • Zanatta, Leila C B; Universidade Federal do Paraná. Divisão de Endocrinologia (SEMPR). Departamento de Medicina Interna. Curitiba. BR
  • Boguszewski, Cesar L; Universidade Federal do Paraná. Divisão de Endocrinologia (SEMPR). Departamento de Medicina Interna. Curitiba. BR
  • Borba, Victoria Z C; Universidade Federal do Paraná. Divisão de Endocrinologia (SEMPR). Departamento de Medicina Interna. Curitiba. BR
  • Moreira, Carolina A; Universidade Federal do Paraná. Divisão de Endocrinologia (SEMPR). Departamento de Medicina Interna. Curitiba. BR
Arch. endocrinol. metab. (Online) ; 62(4): 446-451, July-Aug. 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-950080
ABSTRACT
ABSTRACT

Objective:

Osteocalcin has been associated with several effects on energy and glucose metabolism. However, the physiological role of undercarboxylated osteocalcin (U-osc; the hormonally active isoform of osteocalcin) is still controversial. To correlate the serum levels of U-osc with bone mineral density (BMD) values and metabolic parameters in postmenopausal women. Subjects and

methods:

Cross-sectional study including 105 postmenopausal women (age 56.5 ± 6.1 years, body mass index [BMI] 28.2 ± 4.9 kg/m2) grouped based on the presence of three or less, four, or five criteria of metabolic syndrome according to the International Diabetes Federation (IDF). The subjects underwent dualenergy x-ray absorptiometry (DXA) for the assessment of body composition and BMD and blood tests for the measurement of U-osc and bone-specific alkaline phosphatase (BSAP) levels.

Results:

The mean U-osc level was 3.1 ± 3.4 ng/mL (median 2.3 ng/mL, range 0.0-18.4 ng/mL) and the mean BSAP level was 12.9 ± 4.0 ng/mL (median 12.1 ng/mL, range 73-24.4 ng/mL). There were no associations between U-osc and BSAP levels with serum metabolic parameters. Lower fasting glucose levels were observed in participants with increased values of U-osc/femoral BMD ratio (3.61 ± 4 ng/mL versus 10.2 ± 1.6 ng/mL, p = 0.036). When the participants were stratified into tertiles according to the U-osc/ femoral BMD and U-osc/lumbar BMD ratios, lower fasting glucose levels correlated with increased ratios (p = 0.029 and p = 0.042, respectively).

Conclusion:

Based on the ratio of U-osc to BMD, our study demonstrated an association between U-osc and glucose metabolism. However, no association was observed between U-osc and metabolic parameters.The U-osc/BMD ratio is an innovative way to correct the U-osc value for bone mass.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Densidad Ósea / Osteocalcina / Posmenopausia / Síndrome Metabólico Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Paraná/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Densidad Ósea / Osteocalcina / Posmenopausia / Síndrome Metabólico Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Paraná/BR