TGF-ß1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
Biol. Res
;
48: 1-5, 2015. ilus, graf, tab
Artículo
en Inglés
| LILACS
| ID: biblio-950790
ABSTRACT
BACKGROUND: Transforming growth factor (TGF)-ß is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the correlation between transforming growth factor beta 1 (TGF-ß1) expression and prognosis in intrahepatic cholangiocarcinoma RESULTS: We examined the expression of TGF-ß1 in 78 intrahepatic cholangiocarcinomas by immunohistochemistry and correlated the expression with clinicopathological parameters. TGF-ß1 was expressed in 37 of 78 (47.4 %) intrahepatic cholangiocarcinomas. The expression of TGF-ß1 was significantly correlated with lymph node metastasis, distant metastasis, and tumour recurrence. Patients with TGF-ß1-positive tumours had significantly shorter survival time. In a multivariant analysis, the expression of TGF-ß1 and the tumour stage were independent prognostic factors CONCLUSIONS: Our data suggest that expression of TGF-ß1 is a novel prognostic marker for intrahepatic cholangiocarcinoma.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Colangiocarcinoma
/
Factor de Crecimiento Transformador beta1
/
Neoplasias Hepáticas
/
Proteínas de Neoplasias
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
180th Hospital of People's Liberation Army/CN
/
Eighth People's Hospital of Qingdao/CN
/
Tianjin Medical University General Hospital/CN
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