Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
Biol. Res
;
48: 1-8, 2015. ilus, graf
Artículo
en Inglés
| LILACS
| ID: biblio-950801
ABSTRACT
BACKGROUND:
Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant.RESULTS:
In this study we revealed that a new microRNA (miR), the miR-221, was highly expressed in the glioma cells, and suppression of miR-221 resulted in decreased cellular proliferation, migration, and invasion in glioma cells. Mechanistic experiments validated that miR-221 participates in regulating glioma cells proliferation and invasion via suppression of a direct target gene, the Semaphorin 3B (SEMA3B). The rescue experiment with miR-221 and SEMA3B both knockdown results in significant reversion of miR-221 induced phenotypes.CONCLUSION:
Taken together, our findings highlight an unappreciated role for miR-221 and SEMA3B in glioma.
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Asunto principal:
Neoplasias Encefálicas
/
Glicoproteínas de Membrana
/
Apoptosis
/
Semaforinas
/
MicroARNs
/
Proliferación Celular
/
Glioma
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Capital Medical University/CN
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