Genetic variants associated with neurodegenerative Alzheimer disease in natural models
Biol. Res
;
49: 1-9, 2016. graf, tab
Artículo
en Inglés
| LILACS
| ID: biblio-950841
ABSTRACT
The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Variación Genética
/
Modelos Animales de Enfermedad
/
Enfermedad de Alzheimer
Tipo de estudio:
Factores de riesgo
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Valparaiso/CL
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