A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats
Biol. Res
;
49: 1-6, 2016. graf, tab
Artículo
en Inglés
| LILACS
| ID: biblio-950842
ABSTRACT
BACKGROUND:
It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats.RESULTS:
The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats.CONCLUSIONS:
HFD decreases GABA levels in the FC and hippocampus of rat, which likely disrupts the GABAergic inhibitory processes, underlying feeding behavior.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Dieta Alta en Grasa
/
Lóbulo Frontal
/
Ácido gamma-Aminobutírico
/
Hipocampo
Tipo de estudio:
Estudios de evaluación
Límite:
Animales
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
México
Institución/País de afiliación:
Universidad de Guanajuato/MX
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