Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
Biol. Res
;
49: 1-9, 2016. ilus, graf
Artículo
en Inglés
| LILACS
| ID: biblio-950859
ABSTRACT
BACKGROUND:
Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery systems is being actively researched and reported in the literatureRESULTS:
In this study, we used chitosan-coated levodopa liposomes to investigate the behavioral character and the expression of phosphorylated extracellular signal-regulated kinase (ERK1/2), dopamine- and cAMP-regulated phos-phoprotein of 32 kDa (DARPP-32) and FosB/AFosB in striatum of rat model of levodopa-induced dyskinesia (LID). We found that scores of abnormal involuntary movement (AIM) decreased significantly in liposome group (P < 0.05), compared with levodopa group. Levels of phospho-ERK1/2, phospho-Thr34 DARPP-32 and FosB/AFosB in striatum decreased significantly in liposome group lesion side compared with levodopa group (P < 0.05). However, both of two groups above have significantly differences compared with the control group (P < 0.05).CONCLUSION:
Chitosan-coated levodopa liposomes may be useful in reducing dyskinesias inducing for Parkinson disease. The mechanism might be involved the pathway of signaling molecular phospho-ERK1/2, phospho-Thr34 DARPP-32 and AFosB in striatum
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Dopaminérgicos
/
Levodopa
/
Proteínas Proto-Oncogénicas c-fos
/
Quitosano
/
Discinesia Inducida por Medicamentos
/
Fosfoproteína 32 Regulada por Dopamina y AMPc
Tipo de estudio:
Estudio de etiología
/
Estudios de evaluación
/
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
China Pharmaceutical University/CN
/
Guangdong Pharmaceutical University/CN
/
Huazhong University of Science and Technology/CN
/
Weifang People's Hospital/CN
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